![]() Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, et al. ![]() A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Roles of RUNX in Hippo pathway signaling. ![]() Passaniti A, Brusgard JL, Qiao Y, Sudol M, Finch-Edmondson M. The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Lamar JM, Stern P, Liu H, Schindler JW, Jiang Z, Hynes RO. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway. Pan Y, Han M, Zhang X, He Y, Yuan C, Xiong Y, et al. DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6. Zhang X, Hu Y, Pan Y, Xiong Y, Zhang Y, Han M, et al. Interaction of discoidin domain receptor 1 with collagen type 1. Discoidin domain receptors: microenvironment sensors that promote cellular migration and invasion. Cell softness regulates tumorigenicity and stemness of cancer cells. Lv J, Liu Y, Cheng F, Li J, Zhou Y, Zhang T, et al. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. Clinical and therapeutic implications of cancer stem cells. Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, et al. Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells. You Y, Zheng Q, Dong Y, Xie X, Wang Y, Wu S, et al. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, et al. Collagens and cancer associated fibroblasts in the reactive stroma and its relation to cancer biology. Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion. Sun X, Wu B, Chiang H, Deng H, Zhang X, Xiong W, et al. Collagen density regulates the activity of tumor-infiltrating T cells. Kuczek DE, Larsen AMH, Thorseth M, Carretta M, Kalvisa A, Siersbæk MS, et al. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion. Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, et al. Collagen 1A1 (COL1A1) is a reliable biomarker and putative therapeutic target for hepatocellular carcinogenesis and metastasis. Ma H, Chang H, Bamodu OA, Yadav VK, Huang T, Wu ATH, et al. Viral hepatitis and hepatocellular carcinoma: etiology and management. These findings reveal the molecular basis of collagen I-DDR1 signaling inhibiting Hippo signaling and highlight the role of CD44/DDR1/YAP axis in promoting cancer cell stemness, suggesting that DDR1 and YAP may serve as novel prognostic biomarkers and therapeutic targets in HCC. ![]() A radiomic model based on T2 weighted images can noninvasively predict collagen I expression. The combined inhibition of DDR1 and YAP synergistically abrogated HCC cell stemness in vitro and tumorigenesis in vivo. Mechanistically, DDR1 interacts with CD44, which acts as a co-receptor that amplifies collagen I-induced DDR1 signaling, and collagen I-DDR1 signaling antagonized Hippo signaling by facilitating the recruitment of PP2AA to MST1, leading to exaggerated YAP activation. Collagen I-induced DDR1 activation enhanced HCC cell stemness in vitro and in vivo. Accordingly, high collagen I levels accompanied by high DDR1 expression are associated with poor prognoses in patients with HCC. We found that in advanced HCC tissues, collagen I was upregulated, which is consistent with the expression of its receptor DDR1. However, the concrete mechanism of CSCs in hepatocellular carcinoma (HCC) remains obscure. Cancer stem cells (CSCs) are a minority population of cancer cells with stemness and multiple differentiation potentials, leading to cancer progression and therapeutic resistance. ![]()
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