The law of reflection states that θ1 = θ1’. Instead, retroreflection involves multiple regular reflections to manipulate a light beam to return to its source.įigure 2. Retroreflection is not regular reflection. A regularly reflected ray travels far away from its source according to the law of reflection. In Figure 2, an incoming light ray that strikes a surface (the incident ray) and the regularly reflected ray must form equivalent angles to the normal of the smooth surface. In regular reflection, the reflected beam does not go back towards the direction from which it originated. Traffic signs, bike reflectors, safety vest tape, and other materials that glow when light is cast on them are popularly called “reflective,” but these items are actually retroreflective. An object becomes visible as light bounces off it and enters the eye. A simplified scenario of retroreflection. Beyond road use, retroreflection is used in aerial and maritime radar technology. Retroreflection occurs when a light beam returns in a path parallel from which it came, as demonstrated in Figure 1. Driving at night is possible - and is safer - thanks to retroreflection. The study also found that drivers can see an average distance of 300 feet down a road at night at the minimum retroreflectivity level in California. And forget about the freeway your life would be at risk when making sharp turns or merging lanes! According to a study conducted by the Federal Highway Administration, crash frequency decreases as retroreflectivity increases. What if there was no retroreflection at night? You would be in serious danger of collisions unless you slowed down considerably. This light, which is caused by retroreflection, helps drivers see just about everything that is important to see. The traffic sign that your vehicle approaches has a strong, eye-catching shine, while the road paint within your line of sight glows with almost otherworldly radiance. What you see could never match up to the brilliant sparkle of Guy Diamond from the 2016 Dreamworks hit, Trolls, but I would argue that it comes pretty close. You are a passenger in a vehicle, cruising down the road at night. This optical phenomenon is called retroreflection, and it makes nighttime driving safer by increasing the visibility of road markings and traffic signs. Light on the road is designed to go back towards the direction from which it came during dark conditions. They mostly go unnoticed during the day, but under the cover of darkness, the roads become an optical playground. We encounter retroreflective materials every single day: at street corners, on crosswalks, and almost anywhere that cars can go.
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When she hooked the record-setting dogfish, she said it took about 20 minutes to reel it in, calling it "a little bit of a battle. Ganster spent four or five hours fishing near the Isle of Wight shoal, getting some bluefish and sea bass, before using a piece of bluefish as bait. The trip was unfortunately cancelled due to bad weather, but the Bottom Bouncer fishing charter boat let them come onboard at the last minute. Bottom Bouncer Fishing Charters - Ocean City Maryland Welcome to the Bottom Bouncer The Boat The Bottom Bouncer is a 2003 25 C-Hawk meticulously maintained and serviced with the latest electronics and safety gear, powered by a 2021 Suzuki 300HP outboard. Ganster said she often vacations in Ocean City, and had booked a shark charter trip with her husband months in advance. The Bottom Bouncer is here to provide you with a safe, very affordable, and action packed fishing. The fish's weight was certified at Ocean City's Sunset Marina and a DNR biologist confirmed it. Bottom Bouncer Fishing, Ocean City, Maryland. three and a half times to open a door as well as a password to give the bouncer. The smooth dogfish is part of the shark family, usually swims in packs/schools, and can be caught year-round, said Maryland Department of Natural Resources in a press release. The beach in Ocean City MD is the most popular spot in the city for. Now the Reading, Pa., resident is Maryland's new record holder for the Atlantic Division. Ganster ended up catching an 18-pound smooth dogfish on Oct. Pennsylvania's Fay Ganster hadn't been shark fishing in about 12 years - but when she tried her hand at it in Ocean City last week, she reeled in a big catch. Bottom Bouncer Fishing: OC fishing trip - See 199 customer reviews, photos and charter deals for Ocean City, United States, at FishingBooker. This would be compatible with both 32 bit and 64 bit windows. This is complete offline installer and standalone setup for Avid Pro Tools HD. System Requirements For Avid Pro Tools HDīefore you start Avid Pro Tools HD 10 free download, make sure your PC meets minimum system requirements. Latest Version Release Added On: 07th May 2019.Number one choice for music professionals.Īvid Pro Tools HD 10 Technical Setup Details.Can change pitch of audio track at any time, at any point.Features of Avid Pro Tools HDīelow are some noticeable features which you’ll experience after Avid Pro Tools HD 10 free download. With its ease of use and lightness on the system, it has become the numero uno choice for the users. Or record and create with just your computer and the software alone for ultimate. On a conclusive note we can say that Avid Pro Tools is a must application if you are a music junkie and take breath in the audio mixing. Capture virtual instrument performances using a MIDI keyboard controller. All this is done with the Elastic Pitch transposing function. With this tool you can control the pitch of the sound at any point of the track thus giving you the freedom to change the overall look of the track by altering the pitch. In spite of the fact that the tool is providing some aspiring feature that will blow your mind away its is still light on the system’s resources which is an added advantage. It has a very simple interface which ensure the ease of utilizing this tool in a very productive manner. With this tool in your bag you can create, record, mix music and sounds. Those who are not familiar with it, and I am sure the numbers will be close to zero, are missing a heck of a software. Those who are not using this tool primarily must have it in their bags for future use. The popularity of Avid Pro Tools can be judged by the fact that you enter in any studio of the world you will find out that 9 out of 10 studios have been using this comprehensive audio mixing tool. The software has been widely in use of the professionals and music junkies for recording and mixing audio effects. Pro tools which has been developed by Avid Technology is a platform for audio mixing for Microsoft Windows. It is full offline installer standalone setup of Avid Pro Tools HD v10.3.9. Avid Pro Tools HD 10 Free Download Latest Version for Windows. The pop-up menu below the microphone icon in the Dictation pane of Keyboard preferences shows which device your Mac is currently using to listen. To create a shortcut that’s not in the list, choose Customize, then press the keys you want to use.Click the Shortcut pop-up menu, then choose a different shortcut.Choose Apple menu > System Preferences, click Keyboard, then click Dictation.If you like, you can choose a different dictation keyboard shortcut. Set a different dictation keyboard shortcutīy default, you press the Fn (Function) key twice to start or stop dictation. You can also type or dictate the correct text. If the text is wrong, click it and select an alternate. When you’re done, press the dictation keyboard shortcut or click Done in the feedback window.Īmbiguous text is underlined in blue.For information about setting up dictation for multiple languages, see “Turn on dictation,” above.If you set up dictation for multiple languages and want to switch languages as you dictate, click the language in the feedback window, then choose the language you want.If you’re not using Enhanced Dictation, and you start editing, your dictation session stops. If you’re using Enhanced Dictation, you can use the keyboard, mouse, trackpad, or verbal commands to edit as you go.For a list of the commands you can use while dictating, see Commands for dictating text. For example, say “new line” or “new paragraph” to insert space between lines. You can also perform simple formatting tasks. To insert a punctuation mark, such as a period or comma, say the name of the punctuation mark.When the dictation feedback window shows a microphone icon with a fluctuating loudness indicator, or you hear the tone that signals your Mac is ready for dictation, dictate your text.You can also choose Edit > Start Dictation. Press the dictation keyboard shortcut or, if you enabled the dictation keyword phrase, say the phrase followed by “start dictating,” as in “Computer, start dictating.”.Place the insertion point where you want the dictated text to appear.Remove a language: Click the Language pop-up menu, choose Customize, then deselect the language you don’t want to use.If you’re using Enhanced Dictation, the selected languages are downloaded. Add an unlisted language: Choose Customize or Add Language, then select the languages you want to use. To dictate using another language, click the Language pop-up menu, then choose your language and dialect.For more information, click About Dictation and Privacy.The final converted text appears after you end dictation as described under “Dictate text” below. With server-based dictation, your words are sent to Apple servers to be analyzed using the latest language data. If you don’t want to download the software required to use Enhanced Dictation, you can deselect Enhanced Dictation and use server-based dictation.For more information, see Use the dictation keyword phrase and menu.
Color can breathe new life into a space, however, which is what makes Cal Crystal’s entire line so refreshing. Introducing color to a space can be a tricky thing, and many homeowners choose to avoid it for fear of doing it wrong. That’s what Cal Crystal offers – a wide selection of different knobs and pulls to complete any design, from frosted beach glass pulls to ornate brass bin pulls. Sometimes all a design needs to be complete is a little extra boost, a subtle hint of color or detail that can make you sit up and take notice. With colors like orchid, fuchsia, and kiwi, Cal Crystal has an accent color that is designed to pull the entire room together. Each one of Cal Crystal’s knobs, pulls, and backplates is designed to grab your attention, and to introduce a little extra something to your kitchen or bathroom. By mixing glass, crystal, polyester, and resins with metal finishes such as brass, oil rubbed bronze, and stain nickel, Cal Crystal cabinet hardware is meant to draw and capture the eye.Ĭabinet hardware is always necessary to help your cabinets function properly, but that doesn’t mean that they have to be plain or utilitarian in looks as they do their job. Color and style to make your cabinets and furnishings come alive – that’s what Cal Crystal creates in their colorful and innovative line of cabinet hardware. For larger spaces such as fitness centers or gyms, Weslo recommends its Weslo Commercial Series treadmills. It is meant to be used in the home or apartment setting by one user at a time. Innovative Space Saver Design lets you easily fold your treadmill deck up and out of the way for easy. Q: Can Weslo Cadence G 5.9 Folding Electric Treadmill beside Spacesaver Design be used in a commercial setting?Ī: It is designed for residential use, and not recommended for commercial settings. This makes it an ideal treadmill for home or apartment use. Q: How much space does Weslo Cadence G 5.9 Folding Electric Treadmill among Spacesaver Design take up?Ī: It is designed to be compact, taking up only 40 inches by 18.5 inches of storage space when folded up. Additionally, it features a collapsible design that allows for easy storage. The treadmill also has a low-profile design that prevents accidental tripping and slipping. Q: What safety features does Weslo Cadence G 5.9 Folding Electric Treadmill plus Spacesaver Design have?Ī: It is equipped with an emergency stop button to ensure user safety during workouts. Q: Is Weslo Cadence G 5.9 Folding Electric Treadmill plus Spacesaver Design suitable for heavier users?Ī: It is designed to support users up to 250 pounds, making it suitable for heavier users. Q: What features does Weslo Cadence G 5.9 Folding Electric Treadmill including Spacesaver Design have?Ī: Weslo Cadence G 5.9 Folding Electric Treadmill features a 2-position adjustable incline, Comfort Cell cushioning for less impact on joints, an LCD display that tracks speed, distance, time, and calories burned, a 6-inch backlit display for added visibility during workouts, a low-profile design for easy folding and storage, and two 0.5 HP motors. For a complete workout experience, get the Weslo Cadence G 5.9today! This is a great choice for those looking for an efficient way to stay in shape without having to leave their home. In addition, this electric treadmill has an Easy Pulse heart rate monitor and SmartSelect programming, making it easy to track your progress and stay motivated. Its patented Weslo Cadence cushioning system provides a comfortable walking surface, while its 2.25 HP motor allows for speeds of up to 10 mph and incline levels up to 10%. The Weslo Cadence G 5.9 also offers spacesaver design, allowing you to easily store the treadmill when not in use. This electric treadmill features a 2-position incline and 6 pre-set workouts, allowing you to target different muscle groups for optimal results. The Weslo Cadence G 5.9 Folding Electric Treadmill including Spacesaver Design is the perfect way to get your daily workout in from the comfort of home. While non-governmental human rights organisations have defined Uzbekistan as "an authoritarian state with limited civil rights", significant reforms under Uzbekistan's second president, Shavkat Mirziyoyev, have been made following the death of the first president, Islam Karimov. Uzbekistan comprises 12 regions (vilayats), Tashkent City, and one autonomous republic, Karakalpakstan. Uzbekistan is a secular state, with a presidential constitutional government in place. Shortly before the dissolution of the Soviet Union, it declared independence as the Republic of Uzbekistan on 31 August 1991. In 1924, national delimitation created the Uzbek Soviet Socialist Republic as a republic of the Soviet Union. Conquests by Emperor Babur towards the east led to the foundation of the Mughal Empire in India.Īll of Central Asia was gradually incorporated into the Russian Empire during the 19th century, with Tashkent becoming the political center of Russian Turkestan. The region was split into three states: the Khanate of Khiva, Khanate of Kokand, and Emirate of Bukhara. The territories of the Timurid dynasty were conquered by Uzbek Shaybanids in the 16th century, moving the centre of power to Bukhara. Its capital was Samarkand, which became a centre of science under the rule of Ulugh Beg, giving birth to the Timurid Renaissance. Timur (Tamerlane), who in the 14th century established the Timurid Empire, was from Shahrisabz. The local Khwarazmian dynasty was destroyed by the Mongol invasion in the 13th century, leading to a dominance by Turkic peoples. During this period, cities such as Samarkand, Khiva, and Bukhara began to grow rich from the Silk Road, and became a center of the Islamic Golden Age, with figures such as Muhammad al-Bukhari, Al-Tirmidhi, al Khwarizmi, al-Biruni, Avicenna, and Omar Khayyam. The early Muslim conquests and the subsequent Samanid Empire converted most of the people, including the local ruling classes, into adherents of Islam. The area was incorporated into the Iranian Achaemenid Empire and, after a period of Greco-Bactrian rule, was ruled by the Iranian Parthian Empire and later by the Sasanian Empire, until the Muslim conquest of Persia in the seventh century. The first recorded settlers in what is now Uzbekistan were Eastern Iranian nomads, known as Scythians, who founded kingdoms in Khwarazm, Bactria, and Sogdia in the 8th–6th centuries BC, as well as Fergana and Margiana in the 3rd century BC – 6th century AD. Islam is the predominant religion in Uzbekistan, most Uzbeks being Sunni Muslims. Tajik is also spoken as a minority language, predominantly in Samarkand and Bukhara. Uzbek is the majority-spoken language in Uzbekistan, while Russian is widely spoken and understood throughout the country. Uzbekistan is part of the Turkic world, as well as a member of the Organization of Turkic States. Its capital and largest city is Tashkent. It is surrounded by five landlocked countries: Kazakhstan to the north Kyrgyzstan to the northeast Tajikistan to the southeast Afghanistan to the south and Turkmenistan to the southwest. Uzbekistan ( UK: / ʊ z ˌ b ɛ k ɪ ˈ s t ɑː n, ʌ z-, - ˈ s t æ n/, US: / ʊ z ˈ b ɛ k ɪ s t æ n, - s t ɑː n/ Uzbek: O‘zbekiston, Ўзбекистон, pronounced Russian: Узбекистан), officially the Republic of Uzbekistan ( Uzbek: O‘zbekiston Respublikasi, Ўзбекистон Республикаси), is a doubly landlocked country located in Central Asia. dd.mm.yyyy format is used in Cyrillic scripts, including Russian. The next day was declared a national holiday by the Uzbek government, and became an Independence Day. Pearson JD, Huang K, Pacal M, McCurdy SR, Lu S, Aubry A, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Roles of RUNX in Hippo pathway signaling. Passaniti A, Brusgard JL, Qiao Y, Sudol M, Finch-Edmondson M. The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Lamar JM, Stern P, Liu H, Schindler JW, Jiang Z, Hynes RO. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway. Pan Y, Han M, Zhang X, He Y, Yuan C, Xiong Y, et al. DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6. Zhang X, Hu Y, Pan Y, Xiong Y, Zhang Y, Han M, et al. Interaction of discoidin domain receptor 1 with collagen type 1. Discoidin domain receptors: microenvironment sensors that promote cellular migration and invasion. Cell softness regulates tumorigenicity and stemness of cancer cells. Lv J, Liu Y, Cheng F, Li J, Zhou Y, Zhang T, et al. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. Clinical and therapeutic implications of cancer stem cells. Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, et al. Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells. You Y, Zheng Q, Dong Y, Xie X, Wang Y, Wu S, et al. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, et al. Collagens and cancer associated fibroblasts in the reactive stroma and its relation to cancer biology. Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion. Sun X, Wu B, Chiang H, Deng H, Zhang X, Xiong W, et al. Collagen density regulates the activity of tumor-infiltrating T cells. Kuczek DE, Larsen AMH, Thorseth M, Carretta M, Kalvisa A, Siersbæk MS, et al. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion. Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, et al. Collagen 1A1 (COL1A1) is a reliable biomarker and putative therapeutic target for hepatocellular carcinogenesis and metastasis. Ma H, Chang H, Bamodu OA, Yadav VK, Huang T, Wu ATH, et al. Viral hepatitis and hepatocellular carcinoma: etiology and management. These findings reveal the molecular basis of collagen I-DDR1 signaling inhibiting Hippo signaling and highlight the role of CD44/DDR1/YAP axis in promoting cancer cell stemness, suggesting that DDR1 and YAP may serve as novel prognostic biomarkers and therapeutic targets in HCC. A radiomic model based on T2 weighted images can noninvasively predict collagen I expression. The combined inhibition of DDR1 and YAP synergistically abrogated HCC cell stemness in vitro and tumorigenesis in vivo. Mechanistically, DDR1 interacts with CD44, which acts as a co-receptor that amplifies collagen I-induced DDR1 signaling, and collagen I-DDR1 signaling antagonized Hippo signaling by facilitating the recruitment of PP2AA to MST1, leading to exaggerated YAP activation. Collagen I-induced DDR1 activation enhanced HCC cell stemness in vitro and in vivo. Accordingly, high collagen I levels accompanied by high DDR1 expression are associated with poor prognoses in patients with HCC. We found that in advanced HCC tissues, collagen I was upregulated, which is consistent with the expression of its receptor DDR1. However, the concrete mechanism of CSCs in hepatocellular carcinoma (HCC) remains obscure. Cancer stem cells (CSCs) are a minority population of cancer cells with stemness and multiple differentiation potentials, leading to cancer progression and therapeutic resistance. Workflow 4.7Ī speedy and intuitive workflow is a must for music production, and it’s an area where these controllers shine. It’s not the most common feature in 88-key controllers with hammer-action keys, so it’s particularly nice to see on the S88. We love that aftertouch is included in all models it’s one of the most intuitive ways to add a new dimension to your performance. The built-in arpeggiator is one of the best features because it opens up a world of melodic lines that can provide the desired result quickly and often deliver unexpected results when you need an inspiration boost. Scale mode allows you to map the keyboard to a particular scale, making it easier (especially for less experienced players) to use exotic scales.Ĭhord mode allows you to trigger complex chords with a single key, which can be a massive timesaver for producers of all levels. The S series smart keyboard controllers offer Scale, Chord, and Arpeggiator modes. Touch strips often replace pitch/mod wheels on many controllers, and we generally don’t like to see that, but in this case, you get the best of both worlds! Production tools 4.5 They provide enough range, and smooth action, without being too sensitive. The pitch/mod wheels feel great and somewhat compensate for the lack of faders. The included controls are fantastic a few faders would have been a welcome addition. When playing synth/electronic sounds, tweaking parameters with the assignable knobs is perfect it will feel like a hardware synth.īut, as many media composers will tell you, robust faders are the best tools for adjusting/automating expression in orchestral instruments. But, the lack of faders will bother some users, especially fans of orchestral sounds. You can do a lot with these controls, and the push encoder makes browsing sounds/settings a simple task, as we’ll discuss further below. Rotary knobs and push encoderĮach model has the same set of assignable controls, including eight touch-sensitive rotary knobs and a four-way push encoder. Native Instruments are known to favour a speedy, intuitive workflow, so let’s see what these controllers have to offer. So, it’s very unlikely that you’d have any complaints, but you’ll pay a premium for the experience.Īvailable at: Sweetwater Amazon Assignable controls 4.6Īssignable controls often make or break a MIDI controller. We love them, but they come at a price beyond what we could reasonably call value for money. The S series provides fantastic controllers designed with a smooth workflow in mind, especially when using Native Instruments software. Image credit: Native Instruments Our verdict on the Komplete Kontrol S 4.7 Now, I keep talking about managing environments. Miniconda is installed with ArcGIS Pro although users will never interact directly with Miniconda, as it runs in the background of ArcGIS Pro.ĭifferences between conda, Miniconda, and Anaconda Miniconda includes conda and the base install of Python, while Anaconda includes conda, the base install, an additional 150 modules, and a user interface. There is also a level of bundling between conda and Anancoda called Miniconda. Thus, conda sits at the core of Anaconda and drives much of its functionality. For example, if arcpy requires a specific version of numpy, conda will make sure that you do not update numpy past that version. Additionally, conda allows you to manage packages within each environment, ensures you have the most recent packages, and keeps track of package interdependence. Conda is also a back-end program that leverages and allows other programs, such as Anaconda and Pro, to manage multiple environments. Now that we have a grasp of what the ArcGIS Python API is based on the first part of this blog post, let’s turn to the best practices for installing and using the API, particularly within other software products, such as ArcGIS Pro and Jupyter Notebooks.įirst, we need to take a slight detour into Anaconda, conda, and how they relate to ArcGIS Pro and the ArcGIS API for Python.Īnaconda is a free and open source software package that bundles a Python install and a series of Python packages together with a user interface, allowing users to manage Python environments and packages.Īnaconda also includes conda, which is a package management and environment management system. |
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